Plasma lipids predict myocardial infarction, but not stroke, in patients with established cerebrovascular disease
Identifieur interne : 00A499 ( Main/Exploration ); précédent : 00A498; suivant : 00A500Plasma lipids predict myocardial infarction, but not stroke, in patients with established cerebrovascular disease
Auteurs : Pierre Amarenco [France] ; Anushka Patel [France] ; Mark Woodward [France] ; Duncan J. Campbell [Australie] ; David R. Sullivan [Australie] ; Samuel Colman [France] ; John Chalmers [France] ; Bruce Neal [France] ; Stephen Macmahon [France]Source :
- European heart journal [ 0195-668X ] ; 2005.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
Aims To evaluate the role of plasma lipids in recurrent vascular events, including stroke, among individuals with established cerebrovascular disease. Methods and results Plasma total cholesterol, HDL cholesterol, and triglycerides were measured at baseline among individuals participating in the Perindopril Protection Against Recurrent Stroke (PROGRESS) study, a randomized clinical trial of blood pressure lowering among patients with previous stroke or transient ischaemic attack. A series of nested case-control studies were used to investigate the association between each of these lipid variables and the risk of subsequent haemorrhagic stroke, ischaemic stroke, myocardial infarction (MI), and heart failure. A total of 895 patients were selected as cases (83 haemorrhagic stroke, 472 ischaemic stroke, 206 MI, and 258 heart failure) and each was matched with one to three controls. After adjustment for other major cardiovascular risk factors, none of the lipid variables was associated with the risk of either stroke subtype. There were significant positive and negative associations for total cholesterol and HDL, respectively, with the risk of MI; the odds ratio comparing the highest and lowest thirds of each of these lipid variables was 2.00 (95% CI: 1.30-3.09) for total cholesterol and 0.58 (95% CI: 0.37-0.90) for HDL. HDL was inversely associated with the risk of heart failure; however, this result was of borderline statistical significance (P=0.05). Conclusion Lipid variables are associated with the risk of MI, but not recurrent stroke, in patients with established cerebrovascular disease.
Affiliations:
- Australie, France
- Nouvelle-Galles du Sud, Victoria (État), Île-de-France
- Melbourne, Paris, Sydney
- Université de Melbourne, Université de Sydney
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Sullivan</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Clinical Biochemistry, Royal Prince Alfred Hospital</s1><s2>Sydney</s2><s3>AUS</s3><sZ>5 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Colman, Samuel" sort="Colman, Samuel" uniqKey="Colman S" first="Samuel" last="Colman">Samuel Colman</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology and Stroke Centre, Bichat Hospital and Medical School, Denis Diderot University</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement 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disease</title><author><name sortKey="Amarenco, Pierre" sort="Amarenco, Pierre" uniqKey="Amarenco P" first="Pierre" last="Amarenco">Pierre Amarenco</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology and Stroke Centre, Bichat Hospital and Medical School, Denis Diderot University</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Patel, Anushka" sort="Patel, Anushka" uniqKey="Patel A" first="Anushka" last="Patel">Anushka Patel</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology and Stroke Centre, Bichat Hospital and Medical School, Denis Diderot University</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Woodward, Mark" sort="Woodward, Mark" uniqKey="Woodward M" first="Mark" last="Woodward">Mark Woodward</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology and Stroke Centre, Bichat Hospital and Medical School, Denis Diderot University</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Campbell, Duncan J" sort="Campbell, Duncan J" uniqKey="Campbell D" first="Duncan J." last="Campbell">Duncan J. Campbell</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>The George Institute for International Health, University of Sydney, PO Box M201, Missenden Road</s1><s2>Sydney, NSW 2050</s2><s3>AUS</s3><sZ>4 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Sydney, NSW 2050</wicri:noRegion><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>St Vincent's Institute of Medical Research</s1><s2>Victoria</s2><s3>AUS</s3><sZ>4 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>St Vincent's Institute of Medical Research</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Department of Medicine, University of Melbourne</s1><s2>Victoria</s2><s3>AUS</s3><sZ>4 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Sullivan, David R" sort="Sullivan, David R" uniqKey="Sullivan D" first="David R." last="Sullivan">David R. Sullivan</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Clinical Biochemistry, Royal Prince Alfred Hospital</s1><s2>Sydney</s2><s3>AUS</s3><sZ>5 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Colman, Samuel" sort="Colman, Samuel" uniqKey="Colman S" first="Samuel" last="Colman">Samuel Colman</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology and Stroke Centre, Bichat Hospital and Medical School, Denis Diderot University</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Chalmers, John" sort="Chalmers, John" uniqKey="Chalmers J" first="John" last="Chalmers">John Chalmers</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology and Stroke Centre, Bichat Hospital and Medical School, Denis Diderot University</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Neal, Bruce" sort="Neal, Bruce" uniqKey="Neal B" first="Bruce" last="Neal">Bruce Neal</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology and Stroke Centre, Bichat Hospital and Medical School, Denis Diderot University</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Macmahon, Stephen" sort="Macmahon, Stephen" uniqKey="Macmahon S" first="Stephen" last="Macmahon">Stephen Macmahon</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology and Stroke Centre, Bichat Hospital and Medical School, Denis Diderot University</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">European heart journal</title><title level="j" type="abbreviated">Eur. heart j.</title><idno type="ISSN">0195-668X</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">European heart journal</title><title level="j" type="abbreviated">Eur. heart j.</title><idno type="ISSN">0195-668X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Blood plasma</term><term>Cardiology</term><term>Case control study</term><term>Cerebrovascular disease</term><term>Circulatory system</term><term>Heart failure</term><term>Hemorrhage</term><term>Human</term><term>Ischemia</term><term>Lipids</term><term>Myocardial infarction</term><term>Phlebology</term><term>Prediction</term><term>Stroke</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Infarctus myocarde</term><term>Accident cérébrovasculaire</term><term>Cérébrovasculaire pathologie</term><term>Ischémie</term><term>Plasma sanguin</term><term>Lipide</term><term>Prédiction</term><term>Homme</term><term>Etude cas témoin</term><term>Hémorragie</term><term>Insuffisance cardiaque</term><term>Appareil circulatoire</term><term>Cardiologie</term><term>Phlébologie</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Aims To evaluate the role of plasma lipids in recurrent vascular events, including stroke, among individuals with established cerebrovascular disease. Methods and results Plasma total cholesterol, HDL cholesterol, and triglycerides were measured at baseline among individuals participating in the Perindopril Protection Against Recurrent Stroke (PROGRESS) study, a randomized clinical trial of blood pressure lowering among patients with previous stroke or transient ischaemic attack. A series of nested case-control studies were used to investigate the association between each of these lipid variables and the risk of subsequent haemorrhagic stroke, ischaemic stroke, myocardial infarction (MI), and heart failure. A total of 895 patients were selected as cases (83 haemorrhagic stroke, 472 ischaemic stroke, 206 MI, and 258 heart failure) and each was matched with one to three controls. After adjustment for other major cardiovascular risk factors, none of the lipid variables was associated with the risk of either stroke subtype. There were significant positive and negative associations for total cholesterol and HDL, respectively, with the risk of MI; the odds ratio comparing the highest and lowest thirds of each of these lipid variables was 2.00 (95% CI: 1.30-3.09) for total cholesterol and 0.58 (95% CI: 0.37-0.90) for HDL. HDL was inversely associated with the risk of heart failure; however, this result was of borderline statistical significance (P=0.05). Conclusion Lipid variables are associated with the risk of MI, but not recurrent stroke, in patients with established cerebrovascular disease.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li></country><region><li>Nouvelle-Galles du Sud</li><li>Victoria (État)</li><li>Île-de-France</li></region><settlement><li>Melbourne</li><li>Paris</li><li>Sydney</li></settlement><orgName><li>Université de Melbourne</li><li>Université de Sydney</li></orgName></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Amarenco, Pierre" sort="Amarenco, Pierre" uniqKey="Amarenco P" first="Pierre" last="Amarenco">Pierre Amarenco</name></region><name sortKey="Chalmers, John" sort="Chalmers, John" uniqKey="Chalmers J" first="John" last="Chalmers">John Chalmers</name><name sortKey="Colman, Samuel" sort="Colman, Samuel" uniqKey="Colman S" first="Samuel" last="Colman">Samuel Colman</name><name sortKey="Macmahon, Stephen" sort="Macmahon, Stephen" uniqKey="Macmahon S" first="Stephen" last="Macmahon">Stephen Macmahon</name><name sortKey="Neal, Bruce" sort="Neal, Bruce" uniqKey="Neal B" first="Bruce" last="Neal">Bruce Neal</name><name sortKey="Patel, Anushka" sort="Patel, Anushka" uniqKey="Patel A" first="Anushka" last="Patel">Anushka Patel</name><name sortKey="Woodward, Mark" sort="Woodward, Mark" uniqKey="Woodward M" first="Mark" last="Woodward">Mark Woodward</name></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Campbell, Duncan J" sort="Campbell, Duncan J" uniqKey="Campbell D" first="Duncan J." last="Campbell">Duncan J. Campbell</name></region><name sortKey="Campbell, Duncan J" sort="Campbell, Duncan J" uniqKey="Campbell D" first="Duncan J." last="Campbell">Duncan J. Campbell</name><name sortKey="Campbell, Duncan J" sort="Campbell, Duncan J" uniqKey="Campbell D" first="Duncan J." last="Campbell">Duncan J. Campbell</name><name sortKey="Sullivan, David R" sort="Sullivan, David R" uniqKey="Sullivan D" first="David R." last="Sullivan">David R. Sullivan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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